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Abstract
Protective effect of root extract of operculina turpethum linn. Against paracetamol-induced hepatotoxicity in rats
Author(s): SV Suresh Kumar1, C Sujatha1, J Syamala1, B Nagasudha1, SH Mishra2
1 Department of Pharmacognosy, Sri Padmavathi School of Pharmacy, Tirupati-517 501, India 2 Pharmacy Department, Faculty of Engineering & Technology, M. S. University of Baroda, Vadodara-390 001, India
Correspondence Address:
S V Suresh Kumar Department of Pharmacognosy, Sri Padmavathi School of Pharmacy, Tirupati-517 501 India E-mail: sureshsolleti@yahoo.co.in
1 Department of Pharmacognosy, Sri Padmavathi School of Pharmacy, Tirupati-517 501, India 2 Pharmacy Department, Faculty of Engineering & Technology, M. S. University of Baroda, Vadodara-390 001, India
Correspondence Address:
S V Suresh Kumar Department of Pharmacognosy, Sri Padmavathi School of Pharmacy, Tirupati-517 501 India E-mail: sureshsolleti@yahoo.co.in
The ethanolic extract obtained from roots of Operculina turpethum (Convolvulaceae) were evaluated for hepatoprotective activity in rats by inducing liver damage by paracetamol. The ethanol extract at an oral dose of 200 mg/kg exhibited a significant protective effect by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and total bilirubin. These biochemical observations were supplemented by histopathological examination of liver sections. Silymarin was used as positive control.
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