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Abstract
Protective effect of ginger oil on aspirin and pylorus ligation-induced gastric ulcer model in rats
Author(s): M Khushtar1, V Kumar1, K Javed2, Uma Bhandari1
1 Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India 2 Department of Chemistry, Faculty of Science, Hamdard University, New Delhi-110062, India
Correspondence Address:
Uma Bhandari Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi-110062 India uma_bora@hotmail.com
1 Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India 2 Department of Chemistry, Faculty of Science, Hamdard University, New Delhi-110062, India
Correspondence Address:
Uma Bhandari Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi-110062 India uma_bora@hotmail.com
The present investigation was performed in aspirin and pylorus ligation-induced ulcer model in Wistar rats, in which ability of ginger oil to provide gastric protection was studied at two different doses, 0.5 and 1 g/kg po. Gastric protection was evaluated by measuring the ulcer index, serum λ- GTP levels, total acidity of gastric juice and gastric wall mucus thickness. The results obtained in the present study indicated that ginger oil has a protective action against gastric ulcers induced by aspirin plus pylorus ligation in Wistar rats.
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