Abstract
Protective effect of ethanol extract of Gymnosporia montana (Roth) Bemth. in paracetamol-induced hepatotoxicity in rats
1 Department of Pharmacology, Government Medical College, Bhavnagar - 364 001, India 2 Department of Biochemistry, Government Medical College, Bhavnagar - 364 001, India 3 Department of Pathology, Government Medical College, Bhavnagar - 364 001, India
Correspondence Address:
C B Tripathi CM 31/13, Shantinagar 2, Kaliyabid, Bhawnagar 364001 India E-mail: cbrtripathi@yahoo.co.in.
The aim of the present study was to explore the hepatoprotective activity of the ethanol extract of leaves of Gymnosporia montana (Roth) Bemth. (Family: Celastraceous) against paracetamol-induced hepatotoxicity. Hepatotoxicity in Wistar rats was induced by a single intraperitoneal dose of 500 mg/kg of paracetamol and studied by comparing parameters such as serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase and histopathological examination of liver. Pre and post-treatment with ethanol extract of Gymnosporia montana (Roth) Bemth. at doses of 50 and 100 mg/kg was studied by comparing the above mentioned parameters with silymarin (100 mg/kg) as standard. Both doses of ethanol extract of Gymnosporia montana (Roth) Bemth. were found to be hepatoprotective. Extract at the dose of 100 mg/kg produced effects comparable to those of silymarin. The present study indicates that alcohol extract of Gymnosporia montana (Roth) Bemth. possessed significant hepatoprotective activity.
