Abstract

Various types of cancers have been found to contain long non-coding RNAs. Hepatocellular carcinoma is closely associated with atypical expression of long non-coding RNAs. The cancer genome atlas databases were utilized to detect the expression of LINC00847 in different clinical staging and its clinical relevance in hepatocellular carcinoma. In this research, we found that LINC00847 was upregulated in different clinical stages in hepatocellular carcinoma compared with adjacent non-tumor tissues. Fluorescence in situ hybridization was conducted in addition to ribonucleic acid immunoprecipitation assays to indicate that LINC00847 has the ability of sponging microRNA-218-5p. Functional experiments demonstrated microRNA-218-5p repressed the capabilities of proliferation and invasion in hepatocellular carcinoma cells. Dual luciferase assays demonstrated microRNA-218-5p directly targeting to high mobility group box protein 1 messenger ribonucleic acid in its 3’-untranslated region which regulated high mobility group box protein 1/phosphatidylinositol 3-kinase/protein kinase B pathways to exert its antitumor effects. The discoveries of our research uncovered the vital role of LINC00847 could promote biological effect in hepatocellular carcinoma, through sponging microRNA-218-5p in post-transcriptional regulation of high mobility group box protein 1/phosphatidylinositol 3-kinase/protein kinase B axis.