Abstract

This study aimed to identify the potential adverse physiological effects of sexual performance-enhancing medication. Phosphodiesterase enzyme 5 inhibitors are the most common medications used for the treatment of male erectile dysfunction. In this study, nine cases were administered 5 g tadalafil per orally for 2 d in a week with 3 d intervals over 1 y. In addition to routine ophthalmological examinations, macular optical coherence tomography, electrooculography, and electroretinography test results of all participants were evaluated. Bilateral central serous retinopathy with pathological changes on electrooculography and macular optical coherence tomography was found in one patient with blurred central vision. In another patient with bluish-colored vision, light sensitivity, abnormal electrooculography and electroretinography patterns, and increased thickening of the retinal pigment epithelial layer were observed. This study indicates that phosphodiesterase enzyme 5 inhibitor may cause mild-to-moderate transient ocular adverse effects and visual disturbances, even at intermittent low doses, and these changes often tend to return to normal upon prompt discontinuation of medication.