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Abstract
Physicochemical And Biological Evaluation Of Erythromycin Nicotinate, A New Derivative Of Erythromycin
Author(s): G. P Mohanta, P. K Manna, R Manavalan
A new water-soluble derivative of erythromycin, erythromycin nicotinate, was prepared and the physicochemical properties and biological activities were evaluated. The derivative has also good solubility in organic solvents. The partition coefficient value indicates its possible good penetration in vivo. Antimicrobial potency is 856 μg/mg and in vitro antibacterial spectrum is similar to that of erythromycin base. The LD50 value of the new derivative in mice by intraperitoneal route is 612 mg/kg. The present study indicates that the new derivative is a potential alternative to the existing water soluble derivatives.
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