All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Pharmacological Screening Of Isatin-[N-(2-alkylbenzoxazole-5-carbonyl)] Hydrazones

Author(s): M Saragapani, V. M Reddy

Fifteen different isatin-[N-(2-alkylbenzoxazole-5-carbonyl)] hydrazones prepared earlier were screened for analgesic, antidepressant and H1-antihistaminic activities, and also for their effect on pentobarbi-tone-induced narcosis, by standard methods. Results revealed that three compounds h, n and e possessing a methyl substituent at 7-position of the benzoxazole system could exhibit good analgesic activity, in relation to standard. Five of the test compounds, h, g, j. n and i were to potentiate the pentobarbitone-induced narcosis more powerfully than imipramine HCI. The antidepressant and H1-antihistaminic activities of these compounds were not comparable to those of the standards imipramine HCI and diphenhydramine. HCI, employed in the investigation. Out of all, only compound k was found to exhibit all the tested activities, though to varied extents.

PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report