All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Abstract
Pharmacokinetic evaluation of a developed nicotine transdermal system
Author(s): Shaila Lewis, G Subramanian, S Pandey, N Udupa
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, MAHE, Manipal - 576 104, India
Correspondence Address:
Shaila Lewis Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, MAHE, Manipal - 576 104 India E-mail: s.lewis@manipal.edu
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, MAHE, Manipal - 576 104, India
Correspondence Address:
Shaila Lewis Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, MAHE, Manipal - 576 104 India E-mail: s.lewis@manipal.edu
The plasma concentration time profiles for nicotine were characterized after a single application of nicotine transdermal system to the upper fore arm of healthy smokers. A 12 cm2 system was applied for 24 h. Blood samples were withdrawn at predetermined time intervals. Plasma nicotine concentrations rose rapidly and achieved a mean Cmax value of 14.5 ng/ml .The half life was estimated as 4.78 h and AUC(0-24)181.0 ng.h/ ml. The nicotine transdermal system was well tolerated. The results indicate that the system has potential usefulness in smoking cessation. The pharmacokinetic profiles of marketed patch system was compared with the developed system. Significant difference was observed in the pharmacokinetic parameters.
xxx sunny leone xxx bf, Awek melayu tak lawa, desi bhabi fucks british man maya, indian porn kamasutra, sex video hindi xxx, xxx indian bf video
Full-Text | PDF
