Abstract
Pharmacodynamics of ampicillin sodium transdermal patches in an in vitro infection model
1 Sri Ramakrishna Institute of Paramedical Sciences, College of Pharmacy, Coimbatore-641 044, India 2 Ultra College of Pharmacy, Madurai-625 020, India 3 Institute of Pharmaceutical Technology, Annamalai University, Chidambaram-608 003, India
Correspondence Address:
J Bagyalakshmi Sri Ramakrishna Institute of Paramedical Sciences, College of Pharmacy, Coimbatore-641 044 India E-mail: bagi_972003@yahoo.co.in
The purpose of this study was to examine the activity of ampicillin sodium developed as transdermal patch against Escherichia coli . In the present work, the efficiency of ampicillin sodium against E. coli was investigated in an in vitro infection model which simulates human pharmacokinetics. The E. coli stains were exposed to transdermal patch with different kinds of polymers such as sodium alginate, cellulose acetate phthalate, hydroxypropylmethylcellulose, chitosan and carboxymethylcellulose and the drug releasing capacity was studied through colony-forming units (CFU). The process was carried out for 24 h at 37°. It was found out that hydroxypropylmethylcellulose was the best polymer that gave less number of CFU, followed by carboxyl methyl cellulose, chitosan, cellulose acetate phthalate and sodium alginate.
