Abstract

To investigate the effects of irbesartan hydrochlorothiazide combined with recombinant human brain natriuretic peptide on cardiac function, immune function and intestinal flora in subjects with acute heart failure. 100 subjects with acute heart failure admitted to our hospital from March 2021 to March 2022 were divided into 50 subjects in each group according to different intervention methods. The monotherapy group was handled with conventional therapy, and the combination therapy group was handled with irbesartan hydrochlorothiazide combined with recombinant human brain natriuretic peptide, clinical efficacy, cardiac function, serum myocardial enzymes, cardiac troponin I, immunological functioning, change of intestinal flora and adverse reactions in two groups were contrasted. The monotherapy group vs. the total effective rate of the combination therapy group was higher (92.00 % vs. 74.00 %) (p<0.05). The monotherapy group vs. left ventricular ejection fraction in the combination therapy group was notably higher (p<0.05). Left ventricular end diastolic diameter, left ventricular end systolic diameter and serum creatine kinase, creatinine kinase myocardial band, aspartate transaminase, lactate dehydrogenase, troponin I levels were notably lower than those in the monotherapy group (p<0.05). Comparing the intestinal flora of the two groups, the abundance of Bacteroides in the combination therapy group was notably increased vs. the monotherapy group (p<0.05). The abundance of Fusobacterium, Actinomyces, Proteus and Firmicutes was notably lower than that of the monotherapy group (p<0.05). There was no notable difference in the incidence of adverse reactions between the two groups (p>0.05). Irbesartan hydrochlorothiazide combined with recombinant human brain natriuretic peptide can improve the therapeutic effect of acute heart failure, improve the subject’s cardiac function, reduce the myocardial injury, improve the body immunity, and regulate the intestinal flora structure, so as to promote the subject’s recovery.