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Abstract
Nitroimidazooxazoles # part xxiv, search for antileishmanial agents: 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles as potential antileishmanial agents
Author(s): Shashiprabha1, SP Nayak2, K Sundarraja Rao1, K Nagarajan1, K Shridhara1, E Torreele3, BB Trunz3
1Alkem Laboratories Ltd., R and D Centre, Industrial Estate 4th Phase, Bangalore-560 058, India 2Department of Chemistry, Mangalore University, Mangalagangothri, Mangalore-574 199, India 3Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland
Correspondence Address:
K Nagarajan Alkem Laboratories Ltd., R and D Centre, Industrial Estate 4th Phase, Bangalore-560 058 India E-mail: dknb69@yahoo.com
1Alkem Laboratories Ltd., R and D Centre, Industrial Estate 4th Phase, Bangalore-560 058, India 2Department of Chemistry, Mangalore University, Mangalagangothri, Mangalore-574 199, India 3Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland
Correspondence Address:
K Nagarajan Alkem Laboratories Ltd., R and D Centre, Industrial Estate 4th Phase, Bangalore-560 058 India E-mail: dknb69@yahoo.com
A number of mono and bicyclic nitroimidazoles were screened for in vitro antileishmanial activity. Among these, compounds belonging to the class of nitroimidazo[2,1-b]oxazoles showed moderate to good activity. This class of compounds had been reported previously to have pronounced antitubercular activity, particularly CGI17341 (5a). In the present study (5a) and (5d) and (7) were found to be more potent antileishmanials in vitro than the standard and less toxic in relation to a reference compound. (7) Was earlier formulated to have the phenyl group located on C-2(5b).
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