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Abstract
New spectrophotometric methods for the determination of racecadotril in bulk drug and capsules
Author(s): T Vetrichelvan, S Prabakaran
Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur - 603 319, India
Correspondence Address:
T Vetrichelvan Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur - 603 319 India E-mail: vetrisel@yahoo.com
Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur - 603 319, India
Correspondence Address:
T Vetrichelvan Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur - 603 319 India E-mail: vetrisel@yahoo.com
Two simple and sensitive spectrophotometric methods (A and B) for the determination of racecadotril in bulk drugs and pharmaceutical formulations are described. In method A, methanol was used as solvent and shows absorption maximum at 231 nm. In method B, the solvent used was acetonitrile:water in the ratio of 1:3 and shows absorption maximum at 232 nm. The Beer's law range for method A is 25-100 mg/ml and 20-80 mg/ml for method B. When capsules dosage forms were analyzed, the results obtained by the proposed methods are in good agreement with the labeled amounts and the results were validated statistically.
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