Abstract

Targeted drug delivery is an effective means in cancer chemotherapy. Nanoparticulation is one of the useful means for targeted drug delivery. In the present investigation a broad spectrum anticancer drug methotrexate is nanoparticulated in a foreign protein bovine serum albumin. The particle size distribution was measured using a transmission electron microscope. Two sets of nanoparticles were prepared by varying Protein: drug ratio. The pattern of drug release from the nanoparticles were observed in pH 7.4 at 37o. A non-fickian type of release was observed from both sets.