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Abstract
Microwave assisted synthesis and biological activity of novel coumarinyltriazolothiadiazoles
Author(s): P Manoj Kumar, TK Ravi, R Chawla, S Bhuvana, G Sonia, S Gopalakrishnan
College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641 044, India
Correspondence Address:
P Manoj Kumar College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641 044 India E-mail: kmano1975@rediffmail.com
College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641 044, India
Correspondence Address:
P Manoj Kumar College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641 044 India E-mail: kmano1975@rediffmail.com
A series of new 3-(4-methylcoumarinyl-7-oxymethyl)-6-substitutedphenyl-5,6-dihydro-s-triazolo (3,4-b)(1,3,4)-thiadiazoles 2(a-j) have been synthesized by reacting 5-(4-methyl coumarinyl-7-oxymethyl)-4-amino-3-mercapto(4H)-1,2,4-triazole with various aromatic aldehydes by microwave assisted organic synthesis. The structure of the compounds 2 (a-j) has been confirmed by IR, 1H NMR and mass spectral data. All the compounds were screened for antimicrobial and antioxidant activity. Among the compounds tested, compounds 2d (4-dimethyl amino phenyl derivative) and 2h (3,4-dimethoxy phenyl derivative) showed better antimicrobial and antioxidant activity than rest of the compounds in the series.
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