All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Microemulsion as a vehicle for transdermal permeation of nimesulide

Author(s): DV Derle, BSH Sagar, Sagar Pimpale
Department of Pharmaceutical Sciences, N. D. M. V. P. Samaj's College of Pharmacy, Gangapur Road, Nashik-422 002, India

Correspondence Address:
D V Derle Department of Pharmaceutical Sciences, N. D. M. V. P. Samaj's College of Pharmacy, Gangapur Road, Nashik-422 002 India E-mail: dvderle@hotmail.com


Topical microemulsions of nimesulide, a poorly water-soluble nonsteroidal antiinflammatory drug, using olive oil as oil phase and Tween 80/iso-octanol as surfactant/co-surfactant were designed. Various concentrations of surfactant: co-surfactant (2:1, 3:1, 4:1) were used in constructing a pseudoternary phase diagram. Oil-in-water microemulsions with ratio 15/35/50 (o/w/s) was chosen for the present study after evaluating various parameters like centrifugation, viscosity and stability. Using 4:1 ratio of surfactant : co-surfactant, a microemulsion-based gel of nimesulide was prepared with 1% Carbopol 934. In vitro permeation study of the gel was carried out through excised hairless rat skin and compared with a marketed preparation. The drug release after 24 h from the prepared microemulsion gel and marketed formulation was found to be 72% and 81% respectively. No significant difference was observed between the release rates of nimesulide from both formulations despite their differences in alcohol content. Microemulsion-based gel of poorly water-soluble nimesulide was successfully developed with in vitro release rates comparable to that of the marketed gel formulation.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report