Abstract

To explore the safety and analgesic effect of ketorolac tromethamine on postoperative patients with colorectal cancer. The literature search was conducted in the Chinese databases, i.e. Chinese National Knowledge Infrastructure, Wan Fang, China biology medicine and Virtual IP, and the abroad databases, i.e. PubMed, Web of Science, Embase, Cochrane Library and Joanna Briggs institute for randomized controlled trials, controlled clinical trials and case-control studies about the effects of ketorolac tromethamine on the patients with colorectal cancer after surgery from January 2010 to November 2020, in the languages of Chinese and English. We conducted literature screening and quality evaluation in strict accordance with the standards, and extracted effective data such as study type, sample size, age, intraoperative anesthesia mode and outcome indicators, which were input into RevMan 5.4 software for meta-analysis. A total of 20 literatures, including 13 randomized controlled trials, 6 controlled clinical trials and 1 case-control studies, involving 802 patients. Ketorolac tromethamine had significant lower visual analogue scores of pains at 6 h, 24 h and 48 h, shorter hospital stays and time to first feeding after operation, and lower incidences of ileus, and nausea and vomiting (all p<0.05). Ketorolac tromethamine for the colorectal neoplasms patients is better in the analgesic effect at 6 h, 24 h and 48 h after surgery, effectively shortens the hospital stay and time to first feeding after operation and reduces the incidences of ileus, and nausea and vomiting.