Abstract

By conducting a meta-analysis, this study seeks to examine the efficacy of statins on type 2 diabetes mellitus patients with cardiovascular disease. The key words atuofatating, ruishufatating, tangniaobing and xinxueguanjibing were used to search the Zhongguozhiwang and Wanfang databases, and a comprehensive search was conducted in Cochrane library databases, Embase, Web of Science, and PubMed using the keywords atorvastatin, rosuvastatin, diabetes, and cardiovascular disease. Two evaluators used Cochrane scores to evaluate the quality of articles. Collect relevant data from the included research articles and conduct meta-analysis using RevMan 5.4 software to evaluate the effectiveness of statins. After literature search, selection process and quality evaluation, 11 researches were selected in the meta-analysis. The findings revealed a statistically significant superiority in the enhancement of high-density lipoprotein, total cholesterol, apolipoprotein A1, and apolipoprotein B levels among diabetes patients with cardiovascular disease who received rosuvastatin compared to those treated with atorvastatin. The results suggested that the changes in low-density lipoproteins and triglycerides levels did not differ significantly between the two kinds of patients. This meta-analysis and systematic review confirm that rosuvastatin has significant advantages in improving high-density lipoprotein, total cholesterol, apolipoprotein A1 and apolipoprotein B in diabetes patients with cardiovascular disease, and can be used as a first-line treatment option.