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Abstract
Mercurimetric determination of chlorpropamide by back titration.
Author(s): MG El-Bardicy, SZ El-Khateeb, HN Assaad, AS Ahmad
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini 11562 Cairo (Egypt),
Correspondence Address:
M G El-Bardicy Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini 11562 Cairo (Egypt)
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini 11562 Cairo (Egypt),
Correspondence Address:
M G El-Bardicy Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini 11562 Cairo (Egypt)
A simple titrimetric method for the determination of chlorpropamide based on a precipitation reaction with a known excess of mercuric nitrate solution is reported. The precipitated product was further investigated by both IR and NMR techniwues. The stoichiometry of the reaction pathway was also studied. The proposed method can be adopted by quantities ranging from 30-120 mg authentic drug with a mean recovery of 100.23 +/- 0.96 and the results are comparable with those of the BP 1980 method.
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