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Abstract
Low Frequency Physical Failure Affecting In Vitro Release Of Theophylline From Sustained Release Tablets
Author(s): Smita Shenoy, R Shrivastava
The dissolution test can be used to provide the formulation with valuable information for the design of dosage forms.1 Two marketed sustained release tablets, Product A and Product B, were evaluated for in vitro release using USP XX Type 2 dissolution apparatus at 37±0.5o for a period of 12hrs. Dissolution studies were carried out separately in three different buffers having pH values 1.2, 4.5 and 7.2, at three different paddle speeds, namely, 50,100 and 150 rpm at each pH.
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