Abstract

The expression and correlation of exogenous interleukin-10 and GATA binding protein-3 in the nasal mucosa of allergic rhinitis rats were analyzed. Twenty male Sprague-Dawley rats were randomly divided into two groups; normal control group (group A) and allergic rhinitis group (group B). The interleukin-10 and GATA binding protein-3 in the nasal mucosa of the two groups were determined by immunohistochemistry. The expression levels of GATA binding protein-3 and interleukin-10 were measured by Western blot. Pearson correlation test was used to analyze the correlation between the expression of exogenous interleukin-10 and GATA binding protein-3 in the rat model of allergic rhinitis. The scores of sneezing, runny nose and itching in the group B were reduced than group A. In group A, the epithelial cells of the nasal mucosa were arranged in order, the cilia were complete, and there were a few inflammatory cells and glands under the basement membrane. In group B, the epithelial cells of the nasal mucosa were disordered, the cilia were inverted and absent, the goblet cells in the epithelium were increased, a large number of inflammatory cells such as type selection granulocytes could be seen under the basement membrane, and the gland hyperplasia and vasodilation were obvious. The expression level of interleukin-10 and GATA binding protein-3 in the group B was decreased than control group. The interleukin-10 was positively correlated with GATA binding protein-3. The expression level of interleukin-10 and GATA binding protein-3 in the nasal mucosa of rats with allergic rhinitis was significantly lower than that of rats with allergic rhinitis.