Interactions of Acephate, Glyphosate, Monocrotophos and Phorate with Bovine Serum Albumin

V. Kumar; S. Singh1

doi:10.4172/pharmaceutical-sciences.1000467

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Abstract

Interactions of Acephate, Glyphosate, Monocrotophos and Phorate with Bovine Serum Albumin

Author(s): V. Kumar* and S. Singh¹
Regional Ayurveda Research Institute for Drug Development, Amkhoh, Gwalior-474 009, ¹Department of Biotechnology, Lovely Professional University, Punjab-144 111, India

Correspondence Address:
Regional Ayurveda Research Institute for Drug Development, Amkhoh, Gwalior-474 009, India, E-mail: vijaychem99@gmail.com

DOI: 10.4172/pharmaceutical-sciences.1000467

Binding of pesticides to serum albumin significantly influence their absorption, metabolism, distribution and excretion. In the present study, interactions of acephate, glyphosate, monocrotophos and phorate with bovine serum albumin were explored employing the UV/Vis and Fourier-transform infrared spectroscopy methods. The observed values of binding constant for titled pesticides were. phorate (1.85×10⁷ M^-1)>acephate (3.93×10⁴ M^-1)>glyphosate (1.31×10⁴ M^-1)>monocrotophos (1.12×10⁴ M^-1). Results have shown that out of four pesticides, phorate could show strong interactions with bovine serum albumin.