Abstract

In this present research attempt has been made to enhance the solubility and dissolution of poorly soluble telmisartan by solid dispersion technique using pluronic F127 and implementation of multiple comparison analysis to screen the drug-carrier ratio to optimize the solubility and dissolution. All the solid dispersions were prepared by using various concentrations of drug and carrier and subjected to melting point, solubility and dissolution studies to optimize the drug-carrier ratio. Optimized solid dispersion was also subjected to various analytical studies such as field emission scanning electron microscope, differential scanning calorimetry, X-ray diffraction studies along with stability studies to identify the physico-chemical state of the prepared solid dispersion. It was observed from this research that prepared solid dispersions could able to improve the solubility and dissolution of telmisartan by 6.93 folds and 2.57 folds respectively. Statistical analysis revealed significant difference between telmisartan and prepared telmisartan-pluronic F127 solid dispersion with respect to their solubility and dissolution data. Field emission scanning electron microscope study revealed that distinctive crystalline structure and geometric shape of pure telmisartan was completely disappeared in the prepared solid dispersion which revealed the conversion of crystalline telmisartan to its amorphous form. Differential scanning calorimetry and X-ray diffraction studies confirmed the complete amorphization of drug crystals upon treating with pluronic F127. Stability study also confirmed the stable nature of the prepared telmisartan-pluronic F127 solid dispersion with shelf life of 1.62 y. Finally, it was concluded from the above experimental results that optimized concentration of pluronic F127 could able to improve the solubility and dissolution of telmisartan by solid dispersion technique.