Abstract
Improvement Of Dissolution Rate And Bioavailability Of Piroxicam With Pregelatinized Starch
Piroxicam (PPX) dispersions in pregelatinized starch (PGS) were prepared in different drug and carrier ratios and were characterized by X-ray diffractograms (XRD), differential scanning calorimetry (DSC), differential thermal analysis (DTA) and dissolution studies. Bioavailability studies were conducted on PRX-PGS dispersions and PRX pure drug in healthy human subjects as per cross over randomized block design (RBD). From Time Vs blood concentration data Cmax, Tmax, Ka, AUC and T1/2, were calculated. Higher dissolution rates were noted with dispersions when compared to piroxicam as such. PRX-PGS dispersions also gave fast absorption and higher blood levels of piroxicam when compared to pure drug. All the absorption parameters namely Cmax, percent absorbed In 1 and 2 h, Ka, AUC were higher indicating faster absorption of PRX from dispersions.
