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Abstract
Herb-drug interaction: A case study of effect of ginger on the pharmacokinetic of metronidazole in rabbit
Author(s): JM Okonta1, M Uboh1, WO Obonga2
1Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Nigeria 2Department of Pharmaceutical Chemistry, University of Nigeria, Nsukka, Nigeria
Correspondence Address:
J M Okonta Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka Nigeria E-mail: okojema@yahoo.com
1Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Nigeria 2Department of Pharmaceutical Chemistry, University of Nigeria, Nsukka, Nigeria
Correspondence Address:
J M Okonta Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka Nigeria E-mail: okojema@yahoo.com
The effect of ginger on the pharmacokinectic of metronidazole was studied using rabbits in a crossover study method. The relevance of this study borders on the wide use of ginger for culinary and phytotherapeutic purposes, and metronidazole that is commonly used for every gastrointestinal complain in our communities without prescription. Ginger significantly increased the absorption and plasma half-life, and significantly decreased the elimination rate constant and clearance of metronidazole ( P<0.05). Thus, in clinical practice, the patients should be advised on the serious implication of using both items together.
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