Abstract

Over the past few years, nanotechnology has become an incredibly captivating field of research in science and technology. Due to their superior optical, chemical, photo-electrochemical, and electronic properties over their bulk counterparts, nanomaterials are being used as the cornerstones of nanoscience. The use of different nanostructured materials has revolutionized technology in the field of biology, industry, and medicine. Many bio-molecules like proteins, nucleic acids, and lipids coalesce with nanoparticles in biological systems with minimal toxicity. In this context, circulating protein molecules like albumin can be used as a scaffold for generating an array of nanoparticles for biomedical purposes such as delivery agents for therapeutic use. Albumin protein found in human blood has no immunogenicity as an endogenous protein and ensures its biocompatibility for albumin-based nanoparticles. In the present study, the interaction between silver nanoparticles synthesized from Ocimum leaves and bovine serum albumin protein is carried out under differential temperatures to evaluate the physicochemical characterization of this formed complex. For this purpose, silver nanoparticles are prepared by the bioreduction method and allowed to interact with the native bovine serum albumin. Different in vitro antioxidant assays of the synthesized nanocomposites were also carried out. Hence, exploring the effects of interaction between green synthesized nanoparticles and bovine serum albumin can be useful for designing nanomaterials for nanoscale drug delivery applications in biological systems.