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Abstract
Four antibacterial monoterpenoid derivatives from the herba of Senecio Cannabifolius less
Author(s): B Wu1, WH Lin2, HY Gao1, L Zheng1, LJ Wu1, CS Kim3
1 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China-110 016, 2 School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China-110 016, 3 Faculty of Agriculture, Kochi University, Nankoku, Japan-783-8502
Correspondence Address:
L J Wu School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China-110 016 E-mail: wulijun_111@hotmail.com
1 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China-110 016, 2 School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China-110 016, 3 Faculty of Agriculture, Kochi University, Nankoku, Japan-783-8502
Correspondence Address:
L J Wu School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China-110 016 E-mail: wulijun_111@hotmail.com
Fractionation of a butanol extract of Senecio cannabifolius Less. led to the isolation of two novel monoterpenoid derivatives, named cannabiside D and cannabiside E, whose structures were determined by spectroscopic analyses as 1-(2-hydroxy-2,6,6-trimethyl-4-β-D- glucosyloxy-cyclohexylidene)-butane-2, 3-dione, 6-Hydroxy-3-(3-O-β-D-glucopyranosyl- but-1-enyl)-2, 4,4-trimethyl-cyclohex-2-enone, along with two known glycosides. All the compounds had antibacterial activity, showing particularly potent activity against Staphylococcus aureus IFO 3060 and Bacillus subtilis.
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