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Abstract
Formulation of Enalapril-Loaded Microspheres Using Emulsion Solvent Evaporation Technique for Bitter Taste Masking
Author(s): Y. Gvozdeva*, M. Kassarova and B. Pilicheva
Department of Pharmaceutical Sciences, 1Research Institute, Medical University of Plovdiv, Plovdiv 4000, Bulgaria
Correspondence Address:
Y. Gvozdeva, Department of Pharmaceutical Sciences, 1Research Institute, Medical University of Plovdiv, Plovdiv 4000, Bulgaria, E-mail: yana.gvozdeva@mu-plovdiv.bg
Department of Pharmaceutical Sciences, 1Research Institute, Medical University of Plovdiv, Plovdiv 4000, Bulgaria
Correspondence Address:
Y. Gvozdeva, Department of Pharmaceutical Sciences, 1Research Institute, Medical University of Plovdiv, Plovdiv 4000, Bulgaria, E-mail: yana.gvozdeva@mu-plovdiv.bg
The aim of the present study was to formulate polymer microspheres using the emulsion solvent evaporation technique as an approach to mask the bitter taste of enalapril maleate. Five models were prepared with two water-insoluble polymers. Talc was used to stabilize the particle structure. Production yields ranged from 38 % to 53 %; drug loading varied between 17 % and 40 %; the mean particle size ranged from 140 μm to 339 μm. No interaction between enalapril and the polymers was estimated. A drug release study in artificial saliva indicated a negligible amount of enalapril dissolved in the test medium which demonstrated successful taste masking.
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