Abstract

The aim of the present study was to design nimodipine tablets with fast in vitro release rates using nimodipine-modified gum karaya co-grinding mixtures. Co-grinding mixtures of nimodipine and gum karaya were also prepared to highlight the efficiency of modified gum karaya. Physical mixtures of nimodipine with both the carriers were prepared for comparison. All the solid mixtures were characterized by differential scanning calorimetry and X-ray diffraction studies. Solubility studies and in vitro release rate studies were performed for all the solid mixtures to explain the results. Nimodipine tablets were formulated employing nimodipine-gum karaya/modified gum karaya co-grinding mixtures and their corresponding physical mixtures. The compressed tablets were evaluated for various tablet characteristics including in vitro dissolution rate studies. The best results from the dissolution test were obtained for tablets containing nimodipine-modified gum karaya co-grinding mixtures.