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Abstract
Formulation and evaluation of almotriptan malate nasal drops
Author(s): V Pradhan1, R Gaikwad2, A Samad2, B Prabhakar1
1 School of Pharmacy & Technology Management, SVKM's NMIMS University, V. L. Mehta Road, Vile Parle, Mumbai-400 056, India 2 Bombay Veterinary College, Department of Nuclear Medicine, Parel, Mumbai-400 012, India
Correspondence Address:
V Pradhan School of Pharmacy & Technology Management, SVKM's NMIMS University, V. L. Mehta Road, Vile Parle, Mumbai-400 056 India pradhanvarsha@yahoo.com
1 School of Pharmacy & Technology Management, SVKM's NMIMS University, V. L. Mehta Road, Vile Parle, Mumbai-400 056, India 2 Bombay Veterinary College, Department of Nuclear Medicine, Parel, Mumbai-400 012, India
Correspondence Address:
V Pradhan School of Pharmacy & Technology Management, SVKM's NMIMS University, V. L. Mehta Road, Vile Parle, Mumbai-400 056 India pradhanvarsha@yahoo.com
Nasal solutions of almotriptan malate were prepared in phosphate buffer containing different proportions of HPMC E15. In vitro permeation studies were performed using Franz diffusion cell with dialysis membrane and ex vivo permeation studies were carried out using sheep nasal mucosal layer. The formulations were radiolabeled with 99mTc and the nasal residence time was studied in rabbits. Nasal irritation was evaluated in rats. Formulations prepared with HPMC E15 5% w/v did not retard the release of almotriptan. Gamma scintigraphy studies showed increased residence time as compared to plain drug solution. No nasal irritation was observed and the formulations were found stable for 3 months.
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