Abstract

To investigate the effect of folic acid combined with L-carnitine on vascular endothelial injury in preeclampsia rats by regulating oxidative stress injury and inflammatory factor expression. 42 female Sprague- Dawley rats were randomly divided into normal control group, preeclampsia group and folic acid+L-carnitine group with 14 rats in each group. The rats in folic acid+L-carnitine group were treated with folic acid 3 mg/ kg and 400 mg/kg respectively the rats in normal control group and preeclampsia group were intragastrically given the same amount of normal saline as folic acid+L-carnitine group; from 9 d to 20 d, 75 mg/kg N-nitro-Larginine methyl arginine was subcutaneously injected into the neck and back of rats in preeclampsia group and folic acid+L-carnitine group from 9 d to 20 d. The gestational d 0 and d 5 of each group were compared after 21 d, the percentage of malondialdehyde, 8-iso-prostaglandin F2 alpha, interleukin-6, monocyte chemotactic protein-1, interleukin-1 beta and vascular endothelial microparticles were measured. The changes of femoral artery fibromuscular dysplasia were observed at 0 s, 60 s, 120 s, 180 s, 240 s and 300 s after 21 d. The levels of malondialdehyde and 8-iso-prostaglandin F2 alpha in preeclampsia rats were increased than those in normal control group; and those in folic acid+L-carnitine group were reduced than those in preeclampsia group. The levels of interleukin-6 and monocyte chemotactic protein-1 in preeclampsia rats were raised than those in normal control group; while these in folic acid+L-carnitine group were reduced than those in preeclampsia group. Folic acid combined with L-carnitine can alleviate vascular endothelial injury in preeclampsia rats by regulating oxidative stress injury and expression of inflammatory factors.