Abstract

To found the clinical role of T cell immunoglobulin and mucin domain-containing protein 3 and programmed cell death protein 1 expression from the peripheral blood in patients with colon cancer is the objective of the study. Total of 98 colon cancer patients from our hospital between January 2020 and March 2022 were considered as the study group. An additional 86 healthy subjects from our hospital were considered as the healthy group. Spearman correlation analysis was used to detect the clinical features of the patients and receiver operating characteristic curve were used to detect the diagnosis values of the indexes. The blood expression of T cell immunoglobulin and mucin domain-containing protein 3+, programmed cell death protein 1+ and T cell immunoglobulin and mucin domain-containing protein 3+ programmed cell death protein 1+ were significantly higher in the study group than that in healthy group (p<0.05). Although, there was no significant difference in the expression of T cell immunoglobulin and mucin domain-containing protein 3+, programmed cell death protein 1+ and T cell immunoglobulin and mucin domain-containing protein 3+ programmed cell death protein 1+ in relation to tumor location or distant metastasis (p>0.05), but there was a positive correlation with tumor size and tumor, nodes and metastases stage. The combined diagnosis of peripheral blood T cell immunoglobulin and mucin domain-containing protein 3+, programmed cell death protein 1+ and T cell immunoglobulin and mucin domain-containing protein 3+ programmed cell death protein 1+ showed higher area under the curve=0.964 than a single index examination (p<0.05). Higher T cell immunoglobulin and mucin domain-containing protein 3+, programmed cell death protein 1+ and T cell immunoglobulin and mucin domain-containing protein 3+ programmed cell death protein 1+ cells in peripheral blood can provide a basis for clinical diagnosis and progression of colon cancer.