Abstract

Bone fracture is one of the most significant issues in the world, and it can affect anyone between ages. Patients have, accordingly, focused their attention on complementary and alternative medicine from natural products and applications from the orient; specifically, traditional Chinese medicine, because of efforts to enhance the healing of fractures without undesirable side effects. Although there are many types of traditional Chinese medicine herbs, some of the most common ones that are used in treating osteoporosis are known to have beneficial effects on bone density, where Eucommia ulmoides and Drynariae Rhizome are some of the most used types. In an attempt to determine the effectiveness of active components in the plant Eucommia ulmoides and the herb Drynariae Rhizome in bone fracture and fracture healing using network pharmacology and molecular docking study, this research study was carried out. First, the dosage forms Eucommia ulmoides and Drynariae Rhizome for traditional Chinese medicine nature were obtained, and then the molecular docking and molecular dynamics of the target protein of this medicine were achieveDrynariae To analyze the process of molecular accumulation, the decision to use the presence/absence matrix of known interactions and apply network considerations that recognize three dimensional contacts and biological networks of the compounds and targets involved was made. Based on the conclusions drawn from this molecular docking, the efficiency and working mechanism of the bioactive compounds and their targets were determineDrynariae These bioactive compounds described in the case focus on network pharmacology’s targets, and they might be relational with bone metabolism, fracture repairing or other diseases. Molecular docks also offered fairly reasonable binding through certain metabolites like geniposidic acid and kaempferol with other probable aims like bone morphogenetic protein 2/growth differentiation factor 5 compounds that may back up the restorative wound fix in bone and cartilage, neuroprotection, cardiovascular health, and cancer defence mechanisms. The findings from this integrated approach based on the sequence have the ability to offer better understanding of the phytochemicals that make Eucommia ulmoides and Drynariae Rhizome helpful in the healing of bone fracture. The knowledge regarding the bioactive compound and their relationship with the target protein might help in the development of fresh and effective fracture healing traditional Chinese medicine drugs or in the adjustment of the traditional Chinese medicine prescriptions for bone ailments.