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Abstract
Evaluation of composition and antimicrobial activity of supercritical fluid extract of leaves of Vitex negundo
Author(s): KS Nagarsekar1, MS Nagarsenker2, SR Kulkarni1
1Department of Pharmacognosy and Phytochemistry, Bombay College of Pharmacy, Mumbai-400 098, India 1Department of Pharmaceutics, Bombay College of Pharmacy, Mumbai-400 098, India
Correspondence Address:
S R Kulkarni Department of Pharmacognosy and Phytochemistry, Bombay College of Pharmacy, Mumbai-400 098 India E-mail: svt_kulkarni@yahoo.co.in
1Department of Pharmacognosy and Phytochemistry, Bombay College of Pharmacy, Mumbai-400 098, India 1Department of Pharmaceutics, Bombay College of Pharmacy, Mumbai-400 098, India
Correspondence Address:
S R Kulkarni Department of Pharmacognosy and Phytochemistry, Bombay College of Pharmacy, Mumbai-400 098 India E-mail: svt_kulkarni@yahoo.co.in
Supercritical fluid extract of leaves of Vitex negundo was tested for its antimicrobial potential and was compared with that of ethanol extract, ether extract and hydrodistilled oil of leaves. The chemical constituents of extracts were studied by chromatographic techniques. Extracts were evaluated for antimicrobial potential against bacterial strains like Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and yeast Candida albicans. Extracts showed prominent antibacterial activity against Bacillus subtilis and Staphylococcus aureus. Supercritical fluid extract exhibited good antibacterial potential.
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