Abstract

To study the effects of paeoniflorin on the behavioral manifestations, levels of neurotransmitters in the hippocampus, and axial response in an anxiety model of acute myocardial infarction. 21 rats were randomly divided into 3 groups; control group, acute myocardial infarction+anxiety group, and acute myocardial infarction+anxiety+paeoniflorin group, with 7 rats in each group. An acute myocardial infarction model was constructed by ligating the left anterior descending coronary artery in rats, and mild stress was used to induce anxiety in rats. In the open field test, compared with the horizontal and vertical exercise of the control group, the acute myocardial infarction+anxiety group decreased, and the acute myocardial infarction+anxiety+paeoniflorin group increased compared with the horizontal and vertical exercise of acute myocardial infarction+anxiety group. In the elevated test, compared with the control group, the time of staying at the open arm and entering the open arm was decreased in the acute myocardial infarction+anxiety group, and increased in the acute myocardial infarction+anxiety+paeoniflorin group compared with the acute myocardial infarction+anxiety group. Compared with the control group, chemokine receptor type 4, interleukin-1 beta, interleukin-18 and norepinephrine increased and C-X-C motif chemokine ligand 12 decreased in acute myocardial infarction+anxiety group. Compared with acute myocardial infarction+anxiety group, chemokine receptor type 4, interleukin-1 beta, interleukin-18 and norepinephrine increased and C-X-C motif chemokine ligand 12 decreased in acute myocardial infarction+anxiety+paeoniflorin group. Compared with the control group, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in acute myocardial infarction+anxiety group were higher than those in control group, acute myocardial infarction+anxiety+paeoniflorin 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in acute myocardial infarction+anxiety group were significantly higher than those in acute myocardial infarction+anxiety group, C-X-C motif chemokine ligand 12 and chemokine receptor type 4 protein expression in acute myocardial infarction+anxiety group was higher than that in control group, while acute myocardial infarction+anxiety+paeoniflorin C-X-C motif chemokine ligand 12 and chemokine receptor type 4 protein expression was lower than that in acute myocardial infarction+anxiety group. Paeoniflorin has anti-anxiety effect, can restore the balance of neurotransmitters in hippocampus, and can improve the inflammatory response of acute myocardial infarction with anxiety model.