Abstract

This study aimed to study the effects of comfort interventions combined with drugs on serum 5-hydroxytryptamine and gamma-aminobutyric acid levels and coping styles in patients with neurological tinnitus and analyses them. We selected one hundred neurological tinnitus patients admitted to the hospital from July 2021 to July 2022 for the trial. Then randomly divided them into an experimental group (n=50 cases) and a reference group (n=50 cases) according to the difference between the single and double numbers in the order of medical consultation. The reference group received conventional medication and an audio information therapy device, while the experimental group received additional comfort interventions in addition to the reference group. The disability status, serum 5-hydroxytryptamine and gamma-aminobutyric acid levels, coping style and sleep quality were compared between both groups. After the intervention, experimental group had lower all tinnitus disability scale scores than reference group (all p<0.05). After the intervention, experimental group had lower serum 5-hydroxytryptamine levels but higher gamma-aminobutyric acid levels than reference group (all p<0.05). After the intervention, experimental group had lower facing scores but lower avoidance and submission scores than reference group (all p<0.05). After the intervention, the Athens insomnia scale scores were lower in both groups than before the intervention, and experimental group had lower scores than reference group (both p<0.05). Comfort intervention combined with drugs is effective in improving disability in neurological tinnitus patients, while improving serum 5-hydroxytryptamine and gamma-aminobutyric acid levels and coping style and sleep quality, and is worth promoting.