Abstract

To evaluate the clinical effectiveness of combining hydroxychloroquine with azithromycin for managing rosacea. Our hospital conducted a retrospective investigation on 90 patients with rosacea who sought outpatient care between October 2022 and October 2023. They were divided into control arm and observation, control group was administered hydroxychloroquine and the other group received a combination of hydroxychloroquine+azithromycin. A comparison was made between the two groups regarding the duration of symptom improvement, symptom scores, psychological assessment scores, treatment results. There was remarkable decrease in the duration of clinical symptom improvement in observation compared to the control group. The observation group had better symptom scores and psychological scores after treatment compared to the control group. Combining hydroxychloroquine with azithromycin yields favorable clinical outcomes in rosacea treatment. This combined treatment regimen can significantly shorten the improvement time of clinical symptoms, improve symptom scores and psychological status, and increase the treatment success rate. The incidence of adverse reactions is relatively low. Larger-scale clinical studies and extended follow-up periods are necessary to confirm the efficacy and safety of this treatment.