Abstract

We attempt to discuss the effects of oral Shentong Zhuyu Decoction on the pain degree and serum 5-hydroxytryptophan and prostaglandin E2 of patients with sciatica caused by lumbar disc herniation. We selected 90 patients with sciatica under-treated in the orthopedics department of our hospital from March 2018 to December 2020 as the study cohort. Divided them into experimental group and control group randomly, with 45 patients in both groups and treated patients in control group with mecobalamin tablets, after receiving the same treatment in control group, treated experimental group with another Shentong Zhuyu Decoction. The traditional Chinese medicine syndrome score, visual analog scale score, Oswestry disability index score, Sciatica Bothersomeness index score and serum 5-hydroxytryptophan and prostaglandin E2 of the two groups were compared before treatment, 1 w and 28 d after treatment. 1 w and 28 d after treatment, the decline trend of traditional Chinese medicine syndrome score, visual analog scale score, Oswestry disability index score and Sciatica Bothersomeness index score in experimental group was greater than the other, they were significant different, so it possessed statistical significance (p<0.05). After 7 d and 28 d of treatment for both groups, 5-hydroxytryptophan and prostaglandin E2 of experimental group had a greater downward trend than the other and it possessed significant difference (p<0.05). The total clinical effective rate (86.67 %) of experimental group was remarkably higher than control group (68.89 %), with a remarkable difference (p<0.05). Shentong Zhuyu Decoction can significantly improve the pain degree and clinical effective rate of patients with sciatica caused by lumbar disc herniation and reduce their serum concentration levels of 5-hydroxytryptophan and prostaglandin E2, which is worthy of clinical promotion.