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Abstract
Effect of n,n-diethyl phenyl acetamide : an insect repellent on foetus and reproduction in rats.
Author(s): S Prakash, SS Rao, S Kumar, KM Rao
Defence Research and Development Establishment, Gwalior
Correspondence Address:
S Prakash Defence Research and Development Establishment, Gwalior
Defence Research and Development Establishment, Gwalior
Correspondence Address:
S Prakash Defence Research and Development Establishment, Gwalior
N, N-Diethyl phenyl acetamide in a dose of 1166.6 mg/kg exerted adverse effect on body weight of adult female rats by 14 days' percutaneous application. A 15 day application of the same dose to pregnant females during gestation period caused intrauterine mortality and lower foetal weight. Lower doses of 583 and 145.9 mg/kg body weight corresponding to 1/3 and 1/12 dermal LD 50 did not have any gross adverse effect on foetus, reproduction or post-natal growth of offsprings.
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