Abstract

To investigate the clinical efficacy of modified Tongyou decoction combined with epirubicin, cisplatin and fluorouracil regimen on the pre-thrombotic state in patients with advanced gastric cancer. 142 patients with advanced gastric cancer were selected and were randomly divided into study group and control group, each with 71 patients. The control group was treated with epirubicin, cisplatin and fluorouracil chemotherapy for 6 w, while the study group was treated with Tongyou decoction combined with epirubicin, cisplatin and fluorouracil regimen. After treatment, the levels of serum homocysteine, D-dimer, fibrinogen, blood rheology, clinical efficacy, incidence of venous thrombosis within 1 y, 6 mo survival rate, and 1 y survival rate were statistically compared. After treatment, the serum homocysteine, D-dimer, fibrinogen, whole blood high shear viscosity, whole blood middle shear viscosity, whole blood low shear viscosity, plasma viscosity, and the incidence of venous thrombosis within 1 y of the study group were higher compared with the study group, and the statistically significant difference was p<0.05. Red blood cell deformation index, effective rate were also high in study group. Tongyou decoction combined with epirubicin, cisplatin and fluorouracil chemotherapy can improve the pre-thrombotic state of patients with advanced gastric cancer, improve the therapeutic effect, reduce the incidence of venous thrombosis, and increase 1 y survival rate, which has guiding significance for clinical practice.