Abstract
Effect of mechanical properties on the release of meloxicam from poloxamer gel bases
1 Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, Tandogan Ankara-06100, Turkey 2 Ministry of Health of Turkey, Turkish Medicines and Medical Devices Agency, Sögütözü Mahallesi 2176, Sokak No: 5, Cankaya Ankara-06520, Turkey
Correspondence Address:
O Inal Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, Tandogan Ankara-06100 Turkey E-mail: uzmecz@yahoo.com
Thermoreversible gel of meloxicam, efficient for the treatment of joint diseases, was aimed to prepare for night application available for chronotherapy in this study. Poloxamer 407 and 188 polymers were used at 20-30% w/w as a vehicle in combination with different additives (polyvinylmethylether maleic anhydride copolymer, hydroxypropyl methylcellulose, polyethylene glycol 400, dimethyl sulfoxide, sodium chloride). Characterisation of prepared gels was evaluated by viscosity and texture analysis, and the effect of formulation variables on the gel formulations were evaluated by in vitro drug release and erosion studies. Between the investigated gel bases, Poloxamer 407-hydroxypropyl methylcellulose gel was found to be ideal due to its gel strength (1.560±0.0135 N), viscosity (312.3±2.06 cP) and release characteristics. These promising results could be encouraging for further studies to make it an alternative to commercial dosage forms.
