Abstract

In the present study the hepatoprotective activity of Bramhi Ghrita was tested against carbon tetrachloride-induced hepatotoxicity in rats. The degree of protection was determined by measuring levels of serum marker enzymes, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase and acid phosphatase. Histopathological studies were also carried out to support the above parameters. Bramhi Ghrita is a formulation that belongs to the panchagavya class of Ayurvedic formulations in which one or more of the five products obtained from cow (milk, ghee, curd, urine and dung) are used in combination with herbs. The formulation was administered at doses 100 mg/kg and 300 mg/kg/day to rats. Bramhi ghrita significantly reduces levels of serum marker enzymes serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase and acid phosphatase elevated due to carbon tetrachloride-induced hepatotoxicity. A comparative histopathological study of liver from different groups further corroborated the hepatoprotective activity of Bramhi Ghrita.