Abstract

To explore microRNA-193b-5p diagnostic value and clinical significance in hypertensive disorder complicating pregnancy. A total of 120 hypertensive disorder complicating pregnancy patients (observation group) in our hospital from January 2020 to December 2021 were enrolled was divided into three subgroups: Hypertensive disorders in pregnancy group (42 cases), mild preeclampsia group (43 cases) and severe preeclampsia group (35 cases). 120 healthy pregnant women receiving regular perinatal care were enrolled in the control group. 120 non-pregnant healthy women receiving physical examination were selected as the health control group. MicroRNA-193b-5p and neuregulin-1 levels in three groups were detected and association of microRNA-193b-5p and neuregulin-1 levels and clinical features and disease course was assessed. Receiver operating characteristic evaluated microRNA-193b-5p diagnostic value for hypertensive disorder complicating pregnancy adverse pregnancy outcomes. Serum microRNA-193b-5p and neuregulin-1 in observation group presented up-regulation relative to control group and health control group (p<0.05), while those in control group exhibited up-regulation relative to health control group (p<0.05). Serum microRNA-193b-5p and neuregulin-1 levels in the severe preeclampsia group presented up-regulation relative to mild preeclampsia group and hypertensive disorders in pregnancy group (p<0.05) and those in mild preeclampsia group presented up-regulation relative to hypertensive disorders in pregnancy group (p<0.05). Serum microRNA-193b-5p level in hypertensive disorder complicating pregnancy patients with different ages, body mass index at the time of enrollment and prognosis presented differential significance (p<0.05) and serum microRNA-193b-5p level in hypertensive disorder complicating pregnancy patients with different delivery gestational weeks, gravidity and parity presented no significance (p>0.05). Serum neuregulin-1 level in hypertensive disorder complicating pregnancy patients with different delivery gestational weeks and prognosis presented differential significance (p<0.05) and serum neuregulin-1 level in hypertensive disorder complicating pregnancy patients with different body mass index at the time of enrollment, gravidity and parity presented no significance (p>0.05). Receiver operating characteristic curve demonstrated that microRNA-193b-5p and neuregulin-1 had good predictive performance for adverse pregnancy outcomes of hypertensive disorder complicating pregnancy patients. Serum microRNA-193b-5p and neuregulin-1 play a synergistic mechanism in the onset and progression of hypertensive disorder complicating pregnancy and have association with the onset, progression and prognosis of hypertensive disorder complicating pregnancy, which can be used as valuable biomarkers for the diagnosis of hypertensive disorder complicating pregnancy.