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Abstract

Determination of montelukast sodium and bambuterol hydrochloride in tablets using RP HPLC

Author(s): Smita Patil1, YV Pore1, BS Kuchekar1, Aruna Mane2, VG Khire2
1 Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, 415 124, India 2 Okasa Pharma, L-2, Additional MIDC, Satara-415 004, India

Correspondence Address:
Smita Patil Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, 415 124 India smit1000@rediffmail.com


An accurate, specific and precise assay level gradient reverse-phase high-performance liquid chromatographic method was developed for simultaneous determination of montelukast sodium and bambuterol hydrochloride in tablet dosage form. An inertsil ODS C-18, 5 µm column having 250×4.6 mm I.D. in gradient mode, with mobile phase A, containing 0.025 M sodium phosphate buffer: methanol (85:15) and mobile phase B, containing acetonitrile:methanol (85:15) was used at different time intervals. The flow rate was 1.5 ml/min and effluent was monitored at 218 nm. The retention times of montelukast sodium and bambuterol hydrochloride were 21.2 min and 5.8 min respectively. The linearity for both the drugs was in the range of 0.25-0.75 mg/ml with correlation coefficients of 0.9999 and 0.9996 for montelukast sodium and bambuterol hydrochloride, respectively.

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