Abstract
Biological Activity Of Mannich Bases
Mannich reaction involves condensation of a carbonyl compound with formaldehyde and a secondary amine. It is a mild procedure for obtaining unsaturated ketones (usually -CO-C=CH2). Mannich bases derived from chalcones and 2-dimethyl amino ethyl benzo suberone methiodide have shown promise as anticancer agents, I-Ethyl-6-fluoro-l,4-dihydro-4-oxo-7-[(N4-(5'-chloro-3'- thiosemicarbazono-isatin-I-yl) methyl)-N-piperazinyll-3-quinolinec arboxylic acid had been foundto be more active than norfloxacin.
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