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Abstract
Determination of actarit from human plasma for bioequivalence studies
Author(s): P Loya, MN Saraf
Department of Pharmacology, The Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai - 400 098, India
Correspondence Address:
M N Saraf Department of Pharmacology, The Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai - 400 098 India E-mail: saraf@bcpindia.org
Department of Pharmacology, The Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai - 400 098, India
Correspondence Address:
M N Saraf Department of Pharmacology, The Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai - 400 098 India E-mail: saraf@bcpindia.org
An analytical method based on high-performance liquid chromatography with ultraviolet detection (245 nm) was developed for the determination of actarit in human plasma. Coumarin was used as an internal standard. Chromatographic separation was achieved with a C8 column using a mobile phase of methanol: 1% acetic acid (50-50, v/v) with a flow rate of 1.0 ml/min. The calibration curve was linear over the range of 0.1-4.0 μg/ml (r 2 > 0.99) and the lower limit of quantification was 0.1 μg/ml. The method was validated for sensitivity, accuracy, precision, recovery and stability. The method was used to determine the concentration-time profiles of actarit in the plasma following oral administration of 100 mg actarit tablets.
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