Abstract

A simple technique for making polymeric matrix systems for the controlled release of rifampicin using Eudragit RL100 is described. This method consisted of mixing drug and Eudragit RL100 powder (polymethacrylates) and compressed at room temperature. The compressed fluffy matrices were kept in acetone chamber for 1.5, 3 and 4.5 h for sintering. The sintered tablets were characterized for physical characteristics and subjected to in vitro dissolution studies. The sintering time markedly affected the drug release properties of Eudragit RL100 matrices. It is notable that the release rate of rifampicin from Eudragit RL100 matrices was inversely related to the time of sintering. This may be due to the increase in the extent and firmness of sintering which compacts the mass further so that the drug release is affected. The drug release followed first-order release kinetics with diffusive mechanism.