Abstract

This study compared the efficacy of sodium valproate and perampanel in the treatment of children with epilepsy and their effects on nerve damage and cognitive function. 68 individuals were divided into group A and group B, each with 34 individuals. On the basis of rehabilitation training, group A received sodium valproate treatment, while group B received perampanel treatment. By comparing the duration of epileptic seizures, seizure frequency, blood drug concentration, therapeutic effect, nerve damage and cognitive function, and incidence of adverse drug effects both the groups, impact of the two drugs on the children were evaluated. After medication, the duration and frequency of seizures in the two groups were lower than those before medication, but the duration and frequency of seizures in the sodium valproate group were lower (p<0.05). The blood concentration of group A was lower than that of group B (p<0.05) and there was no significant difference in treatment effect between both the groups (p>0.05). The medication of the two groups had an effect on the nerve injury and cognitive function of the children, and there was no significant difference in comparison (p>0.05). There was no significant difference in the incidence of drug adverse events between the two groups (p>0.05). Both sodium valproate and perampanel have a good curative effect on children with epilepsy, and the drug safety is high. Further, both the drugs effect on the nerve damage and cognitive function of children, but sodium valproate seems to be more effective and is worth recommending for medication.