Abstract
Clinical Efficacy of Docetaxel Combined with Cisplatin in the Treatment of Laryngeal Tumors and Nursing Intervention
Department of Otolaryngology, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu 215600, China
Correspondence Address:
Yan Sun, Department of Otolaryngology, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu 215600, China, E-mail: yangrh169@163.com
To explore the effects of docetaxel combined with cisplatin in the treatment of laryngeal tumors and nursing intervention. A total of 60 laryngeal tumor patients admitted from January 2015 to January 2021 were selected and divided into a control group and an observation group according to the random number table method. The patients in the control group received intravenous drip of cisplatin injection and fluorouracil injection whereas observation group received cisplatin injection and docetaxel injection. At the same time, patients in the control group received routine nursing intervention whereas observation group received comprehensive nursing intervention. The short-term efficacy, toxic and side effects, 1-3 y survival rate, thyroid function and tumor cell apoptosis were compared and analyzed between the two groups. The results showed that the total effective rate of treatment in the observation group was as high as 86.67 %, which was significantly higher than the 63.34 % in the control group. The difference was statistically significant (p<0.05). The incidence of severe toxic and side effects in the observation group was lower than that in the control group, but the difference was not statistically significant (p>0.05). The 1 y and 3 y survival rates in the observation group were 86.67 % and 60.00 %, which were significantly higher than the 66.67 % and 43.33 % in the control group. The difference was statistically significant (p<0.05). After treatment, the thyroid stimulating hormone level in the observation group was significantly higher than that in the control group (p<0.05) and triiodothyronine and tetraiodothyronine levels in the observation group were significantly lower than those in the control group (p<0.05); the apoptosis rate of tumor cells in the observation group was significantly higher than that in the control group [(29.32±2.63) % vs. (20.97±1.69) %]. Docetaxel combined with cisplatin simultaneous radiotherapy has a better clinical effect on laryngeal tumors and a higher survival rate, which is worthy of clinical promotion.
