Abstract
Clinical Effect, Analysis of Amoxicillin Clavulanate Potassium Combined with Shenling Baizhu Powder in the Treatment of Gastric Ulcer with Helicobacter pylori Infection
Department of Gastroenterology, Physical Examination Center, Chengdu Third People’s Hospital, Chengdu, Sichuan Province 610000, P. R. China
Correspondence Address:
Shu Hou, Department of Gastroenterology, Physical Examination Center, Chengdu Third People’s Hospital, Chengdu, Sichuan Province 610000, P. R. China, E-mail: cweo20@163.com
We attempt to investigate the improvement of clinical efficacy of amoxicillin-clavulanate potassium combined with Shenling Baizhu powder in treating gastric ulcer patients with Helicobacter pylori infection and the effect on related serum indexes. We selected 90 patients with gastric ulcer complicated with Helicobacter pylori infection in our hospital from January 2019 to May 2021 and randomly divided them into observation group (45 cases treated with amoxicillin clavulanate potassium combined with Shenling Baizhu powder) and control group (45 cases treated with amoxicillin-clavulanate potassium), compared both groups on the clinical effective rate and Helicobacter pylori eradication rate (per-protocol analysis) before and after treatment, the serum mucosal cytokines (vascular endothelial growth factor, epidermal growth factor, cyclooxygenase-2), matrix metalloproteinase and infection indicators (procalcitonin, C-reactive protein, interleukin-6) concentration level changes. After treatment, observation group possessed remarkably higher serum levels of vascular endothelial growth factor, epidermal growth factor and cyclooxygenase-2 than control group (p<0.05); it possessed remarkably lower procalcitonin, C-reactive protein and interleukin-6 serum levels than control group (p<0.05); and it possessed remarkably lower matrix metalloproteinase-7, matrix metalloproteinase-9 and matrix metalloproteinase plasma levels than control group (p<0.05); after per-protocol analysis, Helicobacter pylori radical cure rate of observation group (86.67 %) was remarkably higher than control group (66.67 %) (p<0.05). Amoxicillin-clavulanate potassium combined with Shenling Baizhu powder can significantly improve the clinical efficacy of gastric ulcer complicated with Helicobacter pylori infection, increase the clearance rate of Helicobacter pylori, increase the level of cellular and mucosal cytokines in serum and reduce the level of serum cytokines. The concentration levels of procalcitonin, C-reactive protein and interleukin-6 can provide clinical guidance value for effectively treating gastric ulcer with Helicobacter pylori infection.
