Abstract
Chemometric Simultaneous Estimation of Clopidogrel Bisulphate and Aspirin from Combined Dosage Form
2 Department of Applied Mathematics, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390 001, India 2 Department of Pharmacy, Pharmaceutical Quality Assurance Laboratory, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390 001, India
Correspondence Address:
S J Rajput Department of Applied Mathematics, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390 001 India E-mail: sjrajput@rediffmail.com
Two chemometric methods, inverse least square and classical least square, were applied to simultaneous assay of clopidogrel bisulphate and aspirin in their combined dosage tablet formulation. Twelve mixed solutions were prepared for the chemometric calibration as training set and 10 mixed solutions were prepared as validation set. The absorbance data matrix was obtained by measuring the absorbance at 16 wavelength points, from 220 to 250 nm with the interval of 2 nm (Dl= 2 nm). The developed calibrations were successfully tested for laboratory mixtures as well as commercial tablet formulation for their clopidogrel bisulphate and aspirin concentration. Mean recoveries for clopidogrel bisulphate and aspirin were found to be in good agreement with the label claim.
